Camellia powder can be used as a functional food to protect liver damage

Camellia powder can be used as a functional food to protect liver damage!

Alcoholism is one of the causes of liver disease. In recent years, due to the increase in drinking frequency and changes in dietary structure, the incidence of alcoholic liver in China has increased significantly, and it has become another liver disease that seriously threatens human health in addition to viral hepatitis, which has drawn great attention from society. Therefore, it is particularly urgent to find natural medicines without side effects to prevent and treat liver diseases.

Studies have shown that many natural foods have hepatoprotective activity, and bee pollen is one of them, such as rapeseed pollen and masson pine pollen, which have been reported. Bee pollen is a cake formed by bees collecting pollen from plant anthers and adding a small amount of saliva after processing. It is known as a "natural nutrition bank".

Previous studies have shown that bee pollen contains more than 250 substances, including lipids (triglycerides), fatty acids, amino acids, vitamins, minerals, phenols, and flavonoids. They have antioxidant, antibacterial, antiviral, and anti-bacterial properties. Inflammation and enhance immunity. Therefore, bee pollen has been widely used as a traditional medicine and health food. Camellia is a kind of bee pollen, which is mainly produced in China. Because of its characteristics of sweet and delicious, fresh smell, it is well received by consumers.

Kao et al. 'S research found that tea pollen has strong antioxidant activity and contains a variety of phenols and flavonoids, such as gallic acid, ferulic acid, caffeic acid, catechins, and rutin. Yildiz et al. Proved that polyphenols and flavonoids in natural foods are related to their liver-protective activities, but so far, research on the hepatoprotective effects of camellia powder has rarely been reported.

The School of Food Science and Engineering of Northwest University and the Shaanxi Bee Product Engineering Technology Research Center have determined the total phenol and total flavonoid content of tea pollen from five places. Based on this, the in vitro antioxidant activity of tea pollen and its effect on alcohol induction were studied. Protective effect of acute liver injury. The results showed that the total phenol and total flavonoid content of Zhejiang tea pollen was the highest, being 8.97 mg / g and 3.01 mg / g, respectively, and had high antioxidant activity. The mice were continuously administrated with tea pollen for 7 weeks, and their ability to absorb oxygen free radicals in the serum increased significantly (P <0 .05="" and="" by="" cu2="" damage="" improved="" induced="" lipid="" peroxidation="" significantly="" span="" the="" was="">

Compared with the model group, the activity of aspartate aminotransferase and alanine aminotransferase in the serum of the tea pollen group decreased significantly (P <0 .05="" 0.05="" a="" activities="" activity="" acute="" alcohol.="" alcohol="" also="" and="" antioxidant="" as="" be="" but="" by="" camellia="" can="" caused="" cell="" content="" damage="" dismutase="" effects="" food="" functional="" glutathione="" has="" he="" improve="" in="" increased="" indicate="" injury.="" injury="" istopathological="" liver="" malondialdehyde="" material="" nbsp="" not="" observations="" obvious="" of="" on="" only="" peroxidase="" pollen="" powder="" protect="" protective="" raw="" reduced="" results="" showed="" significantly="" span="" strong="" study="" superoxide="" tea="" that="" the="" this="" tissue="" to="" used="" was="">

Bee pollen is famous for its rich nutrients and medicinal value. In recent years, there have been more and more functional studies on bee pollen, which has received widespread attention for its functions such as lowering blood lipids, lowering blood sugar, anti-atherosclerosis, and treating the prostate. Camellia pollen, as a kind of bee pollen, has a large output in China and has potential development value, but so far, there are few functional studies on tea pollen. In this study, a model of acute alcoholic liver injury was established by injecting alcohol (5.0 g / kg) into mice at one time to explore the hepatoprotective function of camellia pollen, which provides a theoretical basis for becoming a new type of health food. Polyphenols and flavonoids are a class of antioxidants widely present in plants, and play an important role in the antioxidant activity of natural foods.

This study selected tea pollen from Zhejiang, Anhui, Jiangxi, Sichuan, and Hunan to determine its total phenol and total flavonoid content. The results were 8.41 to 8.97 and 2.23 to 3.01 mg / g, respectively. The results of total phenol and total flavonoid content (8.49, 2.33mg / g) are almost the same. DPPH free radical scavenging ability and FRAP in vitro experiment results show that tea pollen has strong antioxidant activity in vitro and has a very important effect on human health.

In addition, studies have found that Camellia powder can improve the antioxidative capacity of mice in vivo. The ORAC experiment demonstrated that the high-dose group's serum inhibited fluorescence quenching more effectively than the normal group. Similarly, in the experiment of oxidative injury induced by Cu2 + in mouse serum, compared with the normal group, the high-dose group can significantly reduce the formation of lipoprotein oxidation products in the serum, further indicating that tea pollen can enhance the anti-oxidative ability of mouse serum. The catabolism of alcohol in the liver will promote the production of reactive oxygen species (ROS), and excessive accumulation of ROS in the body will cause lipid peroxidation of liver cell membranes and damage liver cells. AST and ALT are aminotransferases present in liver cells. When liver cells are damaged, AST and ALT are released into the blood.

In the study, compared with the normal group, the AST and ALT activities in the serum of the model group mice were significantly increased (P <0 .05="" 6.0g="" a="" action="" activities="" activity="" addition="" administration="" after="" all="" also="" alt="" an="" and="" anion="" as="" ast="" be="" body.="" but="" by="" camellia="" can="" catalase="" cell="" contained="" conversion="" damage.="" damage="" decomposed="" degree="" different="" dna="" doses="" enzyme="" fact="" flavonoids="" free="" function="" further="" gsh-px.="" have="" his="" hydrogen="" important="" in="" indirectly="" injury.="" into="" is="" it="" kg="" lipid="" liver="" may="" mda="" mice="" n="" nbsp="" of="" oxidative="" peroxidation="" peroxide.="" peroxide="" pollen="" product="" promote="" radicals="" reduced="" reducing="" reflect="" related="" ros-removing="" rutin="" serum="" significantly="" span="" such="" superoxide="" tea="" that="" the="" their="" to="" water="" were="" with="">

The study found that the activity of SOD and GSH-Px in the serum of the mice in the model group was significantly reduced, and the MDA content was significantly increased, indicating that the administration of alcohol to the mice will significantly damage the body's antioxidant defense system, leading to the accumulation of ROS and triggering lipid metabolism. Oxidation. After the mice were administrated with tea pollen, the activities of SOD and GSH-Px in the mice were significantly enhanced, and the MDA content was significantly reduced, indicating that the tea pollen can improve the ability of the mice to resist the oxidative damage of ROS attack on biofilms and biomacromolecules This may be related to the fact that gallic acid and caffeic acid in camellia can alleviate inflammation caused by oxidative stress and enhance the activity of SOD and GSH-Px in mice. In addition, histopathological staining observations showed that tea pollen can reduce alcohol-induced liver cell inflammation and infiltration and liver cell death.

To sum up, the content of total phenol and total flavonoids in tea pollen is rich, and has strong antioxidant activity. In addition, in vivo experiments in mice have shown that tea pollen can reduce the activity of AST and ALT in mouse serum, enhance the activity of SOD and GSH-Px in mice, and reduce the content of lipid peroxide MDA. The results show that camellia pollen has protective effects on alcohol-induced acute liver injury. Therefore, camellia can be used as a new type of antioxidant food and as a raw material for producing liver-protecting functional foods.